Drug interactions
Methylprednisolone + Ribociclib
Severity: Moderate
Methylprednisolone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor and can raise methylprednisolone concentrations. This may increase corticosteroid adverse effects such as hyperglycemia, fluid retention and infection risk.
What this interaction means in plain words
Methylprednisolone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of methylprednisolone by ribociclib.
What to do
Monitor for corticosteroid excess (glucose, blood pressure, edema) and consider lowering the methylprednisolone dose if the combination is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Ribociclib?
MediHelp rates the interaction as moderate. Methylprednisolone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate to strong CYP3A4 inhibitor and can raise methylprednisolone concentrations. This may increase corticosteroid adverse effects such as hyperglycemia, fluid retention and infection risk.
How serious is the interaction between Methylprednisolone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess (glucose, blood pressure, edema) and consider lowering the methylprednisolone dose if the combination is prolonged.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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