Drug interactions
Methylprednisolone + Saxagliptin
Severity: Moderate
Methylprednisolone and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids raise blood glucose and can reduce the glycemic benefit of saxagliptin. Any pharmacokinetic effect via CYP3A4 is unlikely to be significant.
What this interaction means in plain words
Methylprednisolone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through steroid-induced hyperglycemia and insulin resistance.
What to do
Monitor blood glucose during steroid therapy and intensify antidiabetic treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Methylprednisolone with Saxagliptin?
MediHelp rates the interaction as moderate. Methylprednisolone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids raise blood glucose and can reduce the glycemic benefit of saxagliptin. Any pharmacokinetic effect via CYP3A4 is unlikely to be significant.
How serious is the interaction between Methylprednisolone and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during steroid therapy and intensify antidiabetic treatment if needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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