Drug interactions
Methylprednisolone + Sirolimus
Severity: Minor
Methylprednisolone and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylprednisolone is commonly co-administered with sirolimus in transplant regimens, and no important pharmacokinetic interaction is established. Additive immunosuppression is intended but raises infection risk.
What this interaction means in plain words
Methylprednisolone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 effect; the main concern is additive immunosuppression rather than a kinetic interaction.
What to do
Monitor sirolimus trough levels as per transplant protocol and watch for infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Sirolimus?
MediHelp rates the interaction as minor. Methylprednisolone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylprednisolone is commonly co-administered with sirolimus in transplant regimens, and no important pharmacokinetic interaction is established. Additive immunosuppression is intended but raises infection risk.
How serious is the interaction between Methylprednisolone and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels as per transplant protocol and watch for infection.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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