Drug interactions
Methylprednisolone + Voriconazole
Severity: Moderate
Methylprednisolone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, the main enzyme clearing methylprednisolone, so systemic corticosteroid exposure rises. This can produce stronger glucocorticoid effects such as hyperglycemia, fluid retention, infection risk and adrenal suppression.
What this interaction means in plain words
Methylprednisolone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of methylprednisolone, reducing its clearance.
What to do
Monitor for corticosteroid excess (glucose, blood pressure, edema, infection) and consider reducing the methylprednisolone dose during combined use. Watch for adrenal suppression when either drug is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Voriconazole?
MediHelp rates the interaction as moderate. Methylprednisolone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, the main enzyme clearing methylprednisolone, so systemic corticosteroid exposure rises. This can produce stronger glucocorticoid effects such as hyperglycemia, fluid retention, infection risk and adrenal suppression.
How serious is the interaction between Methylprednisolone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess (glucose, blood pressure, edema, infection) and consider reducing the methylprednisolone dose during combined use. Watch for adrenal suppression when either drug is stopped.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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