Drug interactions
Metoclopramide + Pheniramine
Severity: Minor
Metoclopramide and Pheniramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pheniramine is a sedating antihistamine with anticholinergic activity. With metoclopramide, additive drowsiness is likely and anticholinergic effects may blunt metoclopramide's prokinetic action.
What this interaction means in plain words
Metoclopramide and Pheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metoclopramide belongs to Gastrointestinal Tract; Pheniramine belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic antagonism of cholinergic prokinetic effect.
What to do
Counsel on sedation and avoid driving until response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Pheniramine
- Amisulpride + Pheniramine Moderate
- Asenapine + Pheniramine Moderate
- Brexpiprazole + Pheniramine Moderate
- Brivaracetam + Pheniramine Moderate
- Cariprazine + Pheniramine Moderate
- Fentanyl + Pheniramine Moderate
Frequently asked questions
Can I take Metoclopramide with Pheniramine?
MediHelp rates the interaction as minor. Metoclopramide and Pheniramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pheniramine is a sedating antihistamine with anticholinergic activity. With metoclopramide, additive drowsiness is likely and anticholinergic effects may blunt metoclopramide's prokinetic action.
How serious is the interaction between Metoclopramide and Pheniramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving until response is known.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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