Drug interactions
Metoclopramide + Procarbazine
Severity: Major
Metoclopramide and Procarbazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity, and metoclopramide can release catecholamines, so hypertensive reactions are possible. Procarbazine also causes sedation and nausea, and added dopamine blockade and serotonergic effects may worsen toxicity.
What this interaction means in plain words
Metoclopramide and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition by procarbazine combined with metoclopramide-induced catecholamine release and additive CNS effects.
What to do
Avoid if feasible and choose an alternative antiemetic. If used, monitor blood pressure and watch for serotonin syndrome and extrapyramidal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metoclopramide and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Metoclopramide
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Metoclopramide with Procarbazine?
MediHelp rates the interaction as major. Metoclopramide and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has monoamine oxidase inhibiting activity, and metoclopramide can release catecholamines, so hypertensive reactions are possible. Procarbazine also causes sedation and nausea, and added dopamine blockade and serotonergic effects may worsen toxicity.
How serious is the interaction between Metoclopramide and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible and choose an alternative antiemetic. If used, monitor blood pressure and watch for serotonin syndrome and extrapyramidal symptoms.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
