Drug interactions
Metoclopramide + Quetiapine
Severity: Major
Metoclopramide and Quetiapine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide with an antipsychotic such as quetiapine adds dopamine blockade and raises the risk of extrapyramidal effects, tardive dyskinesia and neuroleptic malignant syndrome. Quetiapine has relatively weak D2 binding, so the risk may be lower than with other antipsychotics, but it is not eliminated.
What this interaction means in plain words
Metoclopramide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 receptor antagonism.
What to do
Avoid the combination where possible and use an alternative antiemetic. If it cannot be avoided, use the shortest duration and monitor for movement disorders and rigidity or fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Metoclopramide with Quetiapine?
MediHelp rates the interaction as major. Metoclopramide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide with an antipsychotic such as quetiapine adds dopamine blockade and raises the risk of extrapyramidal effects, tardive dyskinesia and neuroleptic malignant syndrome. Quetiapine has relatively weak D2 binding, so the risk may be lower than with other antipsychotics, but it is not eliminated.
How serious is the interaction between Metoclopramide and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiemetic. If it cannot be avoided, use the shortest duration and monitor for movement disorders and rigidity or fever.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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