Drug interactions
Metoclopramide + Ritonavir
Severity: Moderate
Metoclopramide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6, which is a main clearance pathway for metoclopramide, so exposure to metoclopramide may rise. This increases the risk of extrapyramidal symptoms, tardive dyskinesia and sedation.
What this interaction means in plain words
Metoclopramide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6-mediated metoclopramide metabolism by ritonavir.
What to do
Use a reduced metoclopramide dose and monitor for movement disorders and sedation. Consider an alternative antiemetic such as ondansetron with ECG awareness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Metoclopramide with Ritonavir?
MediHelp rates the interaction as moderate. Metoclopramide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6, which is a main clearance pathway for metoclopramide, so exposure to metoclopramide may rise. This increases the risk of extrapyramidal symptoms, tardive dyskinesia and sedation.
How serious is the interaction between Metoclopramide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced metoclopramide dose and monitor for movement disorders and sedation. Consider an alternative antiemetic such as ondansetron with ECG awareness.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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