Drug interactions
Metoclopramide + Sertraline
Severity: Moderate
Metoclopramide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may add to the serotonergic effects of sertraline, raising the risk of serotonin syndrome. Extrapyramidal reactions are also a concern.
What this interaction means in plain words
Metoclopramide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and dopamine D2 antagonism.
What to do
Use the lowest metoclopramide dose for a short duration and monitor for clonus, agitation, hyperthermia and dystonia. Stop metoclopramide if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Metoclopramide with Sertraline?
MediHelp rates the interaction as moderate. Metoclopramide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may add to the serotonergic effects of sertraline, raising the risk of serotonin syndrome. Extrapyramidal reactions are also a concern.
How serious is the interaction between Metoclopramide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest metoclopramide dose for a short duration and monitor for clonus, agitation, hyperthermia and dystonia. Stop metoclopramide if these occur.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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