Drug interactions
Metoclopramide + Tranylcypromine
Severity: Major
Metoclopramide and Tranylcypromine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may trigger catecholamine release, which in patients on a non-selective MAO inhibitor can produce hypertensive crisis. Serotonin toxicity has also been reported with metoclopramide.
What this interaction means in plain words
Metoclopramide and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.
Why it happens
Catecholamine release by metoclopramide in the setting of irreversible non-selective MAO inhibition.
What to do
Avoid the combination and use an alternative antiemetic. If given, monitor blood pressure closely and watch for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Metoclopramide
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Metoclopramide with Tranylcypromine?
MediHelp rates the interaction as major. Metoclopramide and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide may trigger catecholamine release, which in patients on a non-selective MAO inhibitor can produce hypertensive crisis. Serotonin toxicity has also been reported with metoclopramide.
How serious is the interaction between Metoclopramide and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiemetic. If given, monitor blood pressure closely and watch for serotonin toxicity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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