Drug interactions
Metoclopramide + Valproic acid
Severity: Moderate
Metoclopramide and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may increase valproate absorption and add to central sedation, and metoclopramide can rarely worsen seizure control. Valproate can also contribute to extrapyramidal symptoms such as tremor and parkinsonism.
What this interaction means in plain words
Metoclopramide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoclopramide belongs to Gastrointestinal Tract; Valproic acid belongs to Central Nervous System.
Why it happens
Faster gastric emptying increasing valproate absorption, with additive CNS and extrapyramidal effects.
What to do
Monitor valproate levels and seizure control, and watch for sedation and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Metoclopramide with Valproic acid?
MediHelp rates the interaction as moderate. Metoclopramide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may increase valproate absorption and add to central sedation, and metoclopramide can rarely worsen seizure control. Valproate can also contribute to extrapyramidal symptoms such as tremor and parkinsonism.
How serious is the interaction between Metoclopramide and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor valproate levels and seizure control, and watch for sedation and movement disorders.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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