Drug interactions
Metolazone + Mycophenolate mofetil
Severity: Minor
Metolazone and Mycophenolate mofetil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is thought to compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise concentrations of the glucuronide metabolite. The clinical importance is uncertain and the effect is probably small.
What this interaction means in plain words
Metolazone and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metolazone belongs to Cardiovascular; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Possible competition for renal tubular secretion of the mycophenolic acid glucuronide metabolite.
What to do
No routine dose change is needed; monitor for mycophenolate adverse effects such as leukopenia and gastrointestinal intolerance, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Mycophenolate mofetil?
MediHelp rates the interaction as minor. Metolazone and Mycophenolate mofetil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone is thought to compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise concentrations of the glucuronide metabolite. The clinical importance is uncertain and the effect is probably small.
How serious is the interaction between Metolazone and Mycophenolate mofetil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for mycophenolate adverse effects such as leukopenia and gastrointestinal intolerance, particularly in renal impairment.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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