Drug interactions
Metolazone + Nabumetone
Severity: Moderate
Metolazone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazide-like diuretics such as metolazone. Together they may also increase the risk of acute kidney injury, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Metolazone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing diuretic action.
What to do
Monitor blood pressure, edema, weight and serum creatinine and electrolytes when starting or stopping the NSAID. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Nabumetone?
MediHelp rates the interaction as moderate. Metolazone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazide-like diuretics such as metolazone. Together they may also increase the risk of acute kidney injury, especially in volume-depleted or elderly patients.
How serious is the interaction between Metolazone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, weight and serum creatinine and electrolytes when starting or stopping the NSAID. Ensure adequate hydration and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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