Drug interactions
Metolazone + Piroxicam
Severity: Moderate
Metolazone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can lessen the diuretic and antihypertensive effect of metolazone and may contribute to renal impairment in volume-depleted patients.
What this interaction means in plain words
Metolazone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metolazone belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and lowers renal perfusion.
What to do
Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest effective NSAID dose for the shortest period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Metolazone
Frequently asked questions
Can I take Metolazone with Piroxicam?
MediHelp rates the interaction as moderate. Metolazone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can lessen the diuretic and antihypertensive effect of metolazone and may contribute to renal impairment in volume-depleted patients.
How serious is the interaction between Metolazone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest effective NSAID dose for the shortest period.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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