Drug interactions
Metoprolol + Panobinostat
Severity: Moderate
Metoprolol and Panobinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat inhibits CYP2D6 and can raise exposure to sensitive CYP2D6 substrates such as metoprolol. This may increase bradycardia and hypotension. Panobinostat also carries cardiac risks including QT prolongation and arrhythmias.
What this interaction means in plain words
Metoprolol and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Panobinostat belongs to Oncology.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by panobinostat.
What to do
Monitor heart rate, blood pressure and ECG during coadministration. Reduce the metoprolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Metoprolol with Panobinostat?
MediHelp rates the interaction as moderate. Metoprolol and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat inhibits CYP2D6 and can raise exposure to sensitive CYP2D6 substrates such as metoprolol. This may increase bradycardia and hypotension. Panobinostat also carries cardiac risks including QT prolongation and arrhythmias.
How serious is the interaction between Metoprolol and Panobinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during coadministration. Reduce the metoprolol dose if bradycardia or hypotension develops.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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