Drug interactions
Metoprolol + Sevoflurane
Severity: Moderate
Metoprolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics cause vasodilation and myocardial depression, and metoprolol reduces compensatory cardiac responses. Hypotension and bradycardia may be more pronounced during anesthesia.
What this interaction means in plain words
Metoprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metoprolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression from sevoflurane and beta-blockade.
What to do
Generally continue perioperative beta-blockers, and monitor blood pressure and heart rate while adjusting anesthetic depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Metoprolol with Sevoflurane?
MediHelp rates the interaction as moderate. Metoprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics cause vasodilation and myocardial depression, and metoprolol reduces compensatory cardiac responses. Hypotension and bradycardia may be more pronounced during anesthesia.
How serious is the interaction between Metoprolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Generally continue perioperative beta-blockers, and monitor blood pressure and heart rate while adjusting anesthetic depth.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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