Drug interactions
Metyrosine + Thioridazine
Severity: Moderate
Metyrosine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrosine depletes catecholamines and, like antipsychotics, can cause extrapyramidal symptoms and sedation. Used with thioridazine, these effects may be additive.
What this interaction means in plain words
Metyrosine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metyrosine belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
Additive dopamine antagonism or depletion, with inhibition of tyrosine hydroxylase by metyrosine.
What to do
Monitor for parkinsonism, dystonia and sedation, and reduce the dose or use an alternative antipsychotic if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Metyrosine
- Carbidopa-levodopa + Metyrosine Major
- Fluphenazine + Metyrosine Major
- Metoclopramide + Metyrosine Major
- Carbidopa-entacapone-levodopa + Metyrosine Moderate
- Chlorpromazine + Metyrosine Moderate
- Clonidine + Metyrosine Moderate
Frequently asked questions
Can I take Metyrosine with Thioridazine?
MediHelp rates the interaction as moderate. Metyrosine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metyrosine depletes catecholamines and, like antipsychotics, can cause extrapyramidal symptoms and sedation. Used with thioridazine, these effects may be additive.
How serious is the interaction between Metyrosine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for parkinsonism, dystonia and sedation, and reduce the dose or use an alternative antipsychotic if they appear.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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