Drug interactions
Mexiletine + Tasimelteon
Severity: Moderate
Mexiletine and Tasimelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is a CYP1A2 inhibitor that may raise tasimelteon concentrations, increasing sedation, headache and other adverse effects. The magnitude is uncertain because mexiletine is a weaker inhibitor than fluvoxamine, the strong inhibitor referenced in tasimelteon labeling.
What this interaction means in plain words
Mexiletine and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mexiletine belongs to Cardiovascular; Tasimelteon belongs to Central Nervous System.
Why it happens
Mexiletine inhibits CYP1A2, the main enzyme metabolizing tasimelteon.
What to do
Monitor for increased somnolence and adverse effects of tasimelteon. Consider an alternative if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Tasimelteon
Frequently asked questions
Can I take Mexiletine with Tasimelteon?
MediHelp rates the interaction as moderate. Mexiletine and Tasimelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mexiletine is a CYP1A2 inhibitor that may raise tasimelteon concentrations, increasing sedation, headache and other adverse effects. The magnitude is uncertain because mexiletine is a weaker inhibitor than fluvoxamine, the strong inhibitor referenced in tasimelteon labeling.
How serious is the interaction between Mexiletine and Tasimelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased somnolence and adverse effects of tasimelteon. Consider an alternative if tolerability is poor.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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