Drug interactions
Mexiletine + Teriflunomide
Severity: Minor
Mexiletine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer and may lower concentrations of CYP1A2 substrates such as mexiletine. The effect is generally modest but could reduce efficacy.
What this interaction means in plain words
Mexiletine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mexiletine belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide weakly induces CYP1A2 metabolism of mexiletine.
What to do
Monitor clinical response to mexiletine and adjust the dose if efficacy falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mexiletine and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Mexiletine with Teriflunomide?
MediHelp rates the interaction as minor. Mexiletine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer and may lower concentrations of CYP1A2 substrates such as mexiletine. The effect is generally modest but could reduce efficacy.
How serious is the interaction between Mexiletine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to mexiletine and adjust the dose if efficacy falls.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
