Drug interactions
Miconazole + Silodosin
Severity: Moderate
Miconazole and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole could increase silodosin exposure, leading to orthostatic hypotension and dizziness. Systemic absorption from vaginal products is minimal, so clinical significance is mainly with systemic use.
What this interaction means in plain words
Miconazole and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Miconazole belongs to Anti Fungals; Silodosin belongs to Genitourinary.
Why it happens
Miconazole inhibits CYP3A4 and possibly P-glycoprotein, reducing silodosin clearance.
What to do
Avoid systemic miconazole with silodosin. With vaginal use, counsel on postural dizziness and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Miconazole with Silodosin?
MediHelp rates the interaction as moderate. Miconazole and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole could increase silodosin exposure, leading to orthostatic hypotension and dizziness. Systemic absorption from vaginal products is minimal, so clinical significance is mainly with systemic use.
How serious is the interaction between Miconazole and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole with silodosin. With vaginal use, counsel on postural dizziness and monitor blood pressure.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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