Drug interactions
Midazolam + Modafinil
Severity: Minor
Midazolam and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and could partly counter midazolam sedation, while modafinil is also a weak CYP3A4 inducer that may lower midazolam exposure. The overall effect is variable and generally modest.
What this interaction means in plain words
Midazolam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing CNS arousal effects plus possible weak CYP3A4 induction by modafinil.
What to do
Titrate midazolam to clinical response and be aware that higher doses may be needed; do not rely on modafinil to reverse sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Midazolam with Modafinil?
MediHelp rates the interaction as minor. Midazolam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and could partly counter midazolam sedation, while modafinil is also a weak CYP3A4 inducer that may lower midazolam exposure. The overall effect is variable and generally modest.
How serious is the interaction between Midazolam and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical response and be aware that higher doses may be needed; do not rely on modafinil to reverse sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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