Drug interactions
Midazolam + Omaveloxolone
Severity: Moderate
Midazolam and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a weak CYP3A4 inducer and may reduce midazolam exposure. Sedation may be less than expected.
What this interaction means in plain words
Midazolam and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by omaveloxolone increases midazolam clearance.
What to do
Monitor for reduced midazolam effect and titrate to response; consult labeling if substitution is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Midazolam with Omaveloxolone?
MediHelp rates the interaction as moderate. Midazolam and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone is a weak CYP3A4 inducer and may reduce midazolam exposure. Sedation may be less than expected.
How serious is the interaction between Midazolam and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced midazolam effect and titrate to response; consult labeling if substitution is needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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