Drug interactions
Midazolam + Palbociclib
Severity: Moderate
Midazolam and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak CYP3A4 inhibitor and can modestly increase midazolam exposure, particularly with oral or intranasal dosing. This may prolong sedation.
What this interaction means in plain words
Midazolam and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Palbociclib belongs to Oncology.
Why it happens
Time-dependent inhibition of CYP3A4 by palbociclib reduces midazolam clearance.
What to do
Consider a lower midazolam dose and monitor sedation and respiration for longer, especially for non-intravenous routes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Midazolam with Palbociclib?
MediHelp rates the interaction as moderate. Midazolam and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak CYP3A4 inhibitor and can modestly increase midazolam exposure, particularly with oral or intranasal dosing. This may prolong sedation.
How serious is the interaction between Midazolam and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower midazolam dose and monitor sedation and respiration for longer, especially for non-intravenous routes.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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