Drug interactions
Midazolam + Repotrectinib
Severity: Moderate
Midazolam and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib induces CYP3A4 and may reduce midazolam concentrations, risking loss of sedative effect. Oral midazolam is more affected than the intravenous form.
What this interaction means in plain words
Midazolam and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Repotrectinib induction of CYP3A4 accelerates midazolam metabolism.
What to do
Titrate midazolam to clinical effect and monitor for inadequate response, or choose a non-CYP3A4 benzodiazepine. Reassess the dose when repotrectinib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Midazolam with Repotrectinib?
MediHelp rates the interaction as moderate. Midazolam and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repotrectinib induces CYP3A4 and may reduce midazolam concentrations, risking loss of sedative effect. Oral midazolam is more affected than the intravenous form.
How serious is the interaction between Midazolam and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect and monitor for inadequate response, or choose a non-CYP3A4 benzodiazepine. Reassess the dose when repotrectinib is discontinued.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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