Drug interactions
Midazolam + Rucaparib
Severity: Minor
Midazolam and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and can raise exposure to sensitive substrates such as midazolam. This may lead to somewhat stronger or longer sedation, particularly with oral midazolam.
What this interaction means in plain words
Midazolam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midazolam belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing the hepatic and intestinal metabolism of midazolam.
What to do
Monitor sedation and respiratory status when midazolam is given with rucaparib. Reduce the midazolam dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Midazolam with Rucaparib?
MediHelp rates the interaction as minor. Midazolam and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and can raise exposure to sensitive substrates such as midazolam. This may lead to somewhat stronger or longer sedation, particularly with oral midazolam.
How serious is the interaction between Midazolam and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status when midazolam is given with rucaparib. Reduce the midazolam dose if excessive sedation occurs.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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