Drug interactions
Midazolam + Trimipramine
Severity: Moderate
Midazolam and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a strongly sedating tricyclic and adds to the CNS and respiratory depressant effects of midazolam. Patients may experience excessive sedation, confusion and hypotension.
What this interaction means in plain words
Midazolam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression through benzodiazepine GABA-A enhancement and tricyclic antihistaminic and anticholinergic activity.
What to do
Start with reduced midazolam doses and titrate slowly while monitoring sedation and respiratory rate. Avoid unsupervised use in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Midazolam with Trimipramine?
MediHelp rates the interaction as moderate. Midazolam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a strongly sedating tricyclic and adds to the CNS and respiratory depressant effects of midazolam. Patients may experience excessive sedation, confusion and hypotension.
How serious is the interaction between Midazolam and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced midazolam doses and titrate slowly while monitoring sedation and respiratory rate. Avoid unsupervised use in elderly patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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