Drug interactions
Midodrine + Nabilone
Severity: Moderate
Midodrine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone can cause drowsiness and also tachycardia and orthostatic changes in blood pressure, while midodrine raises blood pressure through vasoconstriction. The combined effect on blood pressure and heart rate is not well characterized and may be unpredictable.
What this interaction means in plain words
Midodrine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midodrine belongs to Miscellaneous; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Opposing and overlapping hemodynamic effects; the clinical mechanism is not firmly established.
What to do
Monitor blood pressure, including supine and standing readings, and heart rate when starting or adjusting either drug. Adjust midodrine dosing if hemodynamic control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Nabilone?
MediHelp rates the interaction as moderate. Midodrine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone can cause drowsiness and also tachycardia and orthostatic changes in blood pressure, while midodrine raises blood pressure through vasoconstriction. The combined effect on blood pressure and heart rate is not well characterized and may be unpredictable.
How serious is the interaction between Midodrine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine and standing readings, and heart rate when starting or adjusting either drug. Adjust midodrine dosing if hemodynamic control changes.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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