Drug interactions
Midodrine + Trimethoprim
Severity: Minor
Midodrine and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim inhibits renal tubular cation transporters, which may slightly reduce clearance of midodrine's active metabolite. The clinical effect is likely small but could contribute to higher blood pressure in susceptible patients.
What this interaction means in plain words
Midodrine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Midodrine belongs to Miscellaneous; Trimethoprim belongs to Anti Bacterial.
Why it happens
Inhibition of renal tubular secretion via organic cation transporters and MATE proteins.
What to do
Monitor blood pressure, especially supine hypertension, if trimethoprim is added, notably in renal impairment. Reduce midodrine dose if blood pressure rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Other interactions of Trimethoprim
Frequently asked questions
Can I take Midodrine with Trimethoprim?
MediHelp rates the interaction as minor. Midodrine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim inhibits renal tubular cation transporters, which may slightly reduce clearance of midodrine's active metabolite. The clinical effect is likely small but could contribute to higher blood pressure in susceptible patients.
How serious is the interaction between Midodrine and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially supine hypertension, if trimethoprim is added, notably in renal impairment. Reduce midodrine dose if blood pressure rises.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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