Drug interactions
Midostaurin + Oxaliplatin
Severity: Moderate
Midostaurin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation, and oxaliplatin may add to this effect. Combined use can increase arrhythmia risk, especially with electrolyte loss from vomiting or diarrhea.
What this interaction means in plain words
Midostaurin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midostaurin belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Monitor ECG and electrolytes and correct abnormalities. Reassess the regimen if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Oxaliplatin?
MediHelp rates the interaction as moderate. Midostaurin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin has been associated with QT prolongation, and oxaliplatin may add to this effect. Combined use can increase arrhythmia risk, especially with electrolyte loss from vomiting or diarrhea.
How serious is the interaction between Midostaurin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct abnormalities. Reassess the regimen if QTc becomes markedly prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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