Drug interactions
Midostaurin + Solifenacin
Severity: Moderate
Midostaurin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval, and solifenacin may contribute additively. Risk is higher with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Midostaurin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midostaurin belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes during combined use. Switch to a non-QT-prolonging bladder agent if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Solifenacin?
MediHelp rates the interaction as moderate. Midostaurin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midostaurin can prolong the QT interval, and solifenacin may contribute additively. Risk is higher with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Midostaurin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during combined use. Switch to a non-QT-prolonging bladder agent if the QTc lengthens.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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