Drug interactions
Midostaurin + Voriconazole
Severity: Major
Midostaurin and Voriconazole: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises midostaurin and active metabolite exposure by inhibiting CYP3A4, which may increase toxicities such as nausea, infections and pulmonary effects.
What this interaction means in plain words
Midostaurin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Midostaurin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of midostaurin.
What to do
Consider alternative antifungals. If unavoidable, monitor for adverse reactions, especially in the first week, and manage toxicity by interrupting therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Midostaurin with Voriconazole?
MediHelp rates the interaction as major. Midostaurin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole raises midostaurin and active metabolite exposure by inhibiting CYP3A4, which may increase toxicities such as nausea, infections and pulmonary effects.
How serious is the interaction between Midostaurin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative antifungals. If unavoidable, monitor for adverse reactions, especially in the first week, and manage toxicity by interrupting therapy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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