Drug interactions
Mifepristone + Pentamidine
Severity: Major
Mifepristone and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and combining them may increase the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Mifepristone and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mifepristone belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic synergism.
What to do
Use an alternative if possible; otherwise obtain a baseline and follow-up ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Mifepristone with Pentamidine?
MediHelp rates the interaction as major. Mifepristone and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, and combining them may increase the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Mifepristone and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative if possible; otherwise obtain a baseline and follow-up ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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