Drug interactions
Mifepristone + Propofol
Severity: Minor
Mifepristone and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may inhibit CYP2B6, one of the enzymes involved in propofol metabolism, which could modestly raise propofol exposure and prolong sedation. The clinical significance is uncertain because propofol is cleared by several routes, including glucuronidation.
What this interaction means in plain words
Mifepristone and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mifepristone belongs to Endocrine; Propofol belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2B6-mediated propofol metabolism by mifepristone.
What to do
Titrate propofol to clinical effect and allow extra time for recovery if the patient has recently taken mifepristone. No empiric dose reduction is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Propofol?
MediHelp rates the interaction as minor. Mifepristone and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone may inhibit CYP2B6, one of the enzymes involved in propofol metabolism, which could modestly raise propofol exposure and prolong sedation. The clinical significance is uncertain because propofol is cleared by several routes, including glucuronidation.
How serious is the interaction between Mifepristone and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to clinical effect and allow extra time for recovery if the patient has recently taken mifepristone. No empiric dose reduction is needed.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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