Drug interactions
Mifepristone + Ubrogepant
Severity: Moderate
Mifepristone and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ubrogepant is a CYP3A4 substrate and mifepristone inhibits CYP3A4. Exposure to ubrogepant may increase, raising the risk of adverse effects such as nausea and somnolence.
What this interaction means in plain words
Mifepristone and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Ubrogepant belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of ubrogepant.
What to do
Use the lower ubrogepant dose of 50 mg and avoid a second dose within 24 hours as per labeling for moderate/strong CYP3A4 inhibitors. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Mifepristone with Ubrogepant?
MediHelp rates the interaction as moderate. Mifepristone and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ubrogepant is a CYP3A4 substrate and mifepristone inhibits CYP3A4. Exposure to ubrogepant may increase, raising the risk of adverse effects such as nausea and somnolence.
How serious is the interaction between Mifepristone and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower ubrogepant dose of 50 mg and avoid a second dose within 24 hours as per labeling for moderate/strong CYP3A4 inhibitors. Monitor for adverse effects.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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