Drug interactions
Mifepristone + Vilazodone
Severity: Moderate
Mifepristone and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase vilazodone concentrations, raising the risk of dose-related adverse effects such as nausea, diarrhea, insomnia and serotonergic toxicity.
What this interaction means in plain words
Mifepristone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Mifepristone inhibits CYP3A4, reducing vilazodone metabolism.
What to do
Monitor for vilazodone adverse effects and reduce the dose, for example to 20 mg daily, if intolerable effects occur. Watch for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Mifepristone with Vilazodone?
MediHelp rates the interaction as moderate. Mifepristone and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase vilazodone concentrations, raising the risk of dose-related adverse effects such as nausea, diarrhea, insomnia and serotonergic toxicity.
How serious is the interaction between Mifepristone and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone adverse effects and reduce the dose, for example to 20 mg daily, if intolerable effects occur. Watch for signs of serotonin toxicity.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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