Drug interactions
Mirabegron + Mirtazapine
Severity: Minor
Mirabegron and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is metabolised by CYP2D6, CYP1A2 and CYP3A4, so inhibition of one pathway by mirabegron is expected to have a modest effect. Slightly higher levels could increase sedation.
What this interaction means in plain words
Mirabegron and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirabegron belongs to Genitourinary; Mirtazapine belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, one of several pathways of mirtazapine metabolism.
What to do
No routine adjustment is required; monitor for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirabegron with Mirtazapine?
MediHelp rates the interaction as minor. Mirabegron and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirtazapine is metabolised by CYP2D6, CYP1A2 and CYP3A4, so inhibition of one pathway by mirabegron is expected to have a modest effect. Slightly higher levels could increase sedation.
How serious is the interaction between Mirabegron and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for excess sedation.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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