Drug interactions
Mirabegron + Ozanimod
Severity: Moderate
Mirabegron and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, and mirabegron has sympathomimetic activity, so there is a theoretical risk of raised blood pressure and heart rate. Clinical evidence of a significant interaction is limited.
What this interaction means in plain words
Mirabegron and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Ozanimod belongs to Central Nervous System.
Why it happens
Possible additive adrenergic effects with MAO inhibition by ozanimod metabolites; not well established clinically.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Reassess the combination if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mirabegron with Ozanimod?
MediHelp rates the interaction as moderate. Mirabegron and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolites inhibit MAO-B in vitro, and mirabegron has sympathomimetic activity, so there is a theoretical risk of raised blood pressure and heart rate. Clinical evidence of a significant interaction is limited.
How serious is the interaction between Mirabegron and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Reassess the combination if hypertension develops.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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