Drug interactions
Mirabegron + Risperidone
Severity: Moderate
Mirabegron and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is converted to the equally active 9-hydroxyrisperidone by CYP2D6, so the total active moiety changes little. Some increase in parent drug may occur, with a possible rise in extrapyramidal effects or hypotension.
What this interaction means in plain words
Mirabegron and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Risperidone belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, increasing risperidone relative to its metabolite.
What to do
Monitor for extrapyramidal symptoms, sedation and orthostatic hypotension, and reduce the risperidone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Mirabegron with Risperidone?
MediHelp rates the interaction as moderate. Mirabegron and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone is converted to the equally active 9-hydroxyrisperidone by CYP2D6, so the total active moiety changes little. Some increase in parent drug may occur, with a possible rise in extrapyramidal effects or hypotension.
How serious is the interaction between Mirabegron and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and orthostatic hypotension, and reduce the risperidone dose if they occur.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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