Drug interactions
Mirabegron + Tramadol
Severity: Moderate
Mirabegron and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tramadol is activated by CYP2D6 to O-desmethyltramadol, which provides much of its opioid analgesia. Mirabegron inhibition of CYP2D6 may reduce analgesia while raising parent tramadol levels, which contribute to serotonergic and seizure risk.
What this interaction means in plain words
Mirabegron and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Tramadol belongs to Musculoskeletal.
Why it happens
Mirabegron inhibits CYP2D6, reducing conversion of tramadol to its active opioid metabolite.
What to do
Monitor pain control and for serotonergic or neurological adverse effects. Consider a non-CYP2D6-dependent analgesic if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Mirabegron with Tramadol?
MediHelp rates the interaction as moderate. Mirabegron and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tramadol is activated by CYP2D6 to O-desmethyltramadol, which provides much of its opioid analgesia. Mirabegron inhibition of CYP2D6 may reduce analgesia while raising parent tramadol levels, which contribute to serotonergic and seizure risk.
How serious is the interaction between Mirabegron and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and for serotonergic or neurological adverse effects. Consider a non-CYP2D6-dependent analgesic if the response is inadequate.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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