Drug interactions
Mirabegron + Trimipramine
Severity: Moderate
Mirabegron and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is metabolised partly by CYP2D6, and mirabegron may raise its concentration. Higher levels can increase anticholinergic effects, sedation, orthostatic hypotension and cardiac conduction effects.
What this interaction means in plain words
Mirabegron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirabegron belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Mirabegron inhibits CYP2D6, reducing trimipramine clearance.
What to do
Monitor for tricyclic adverse effects and consider lowering the trimipramine dose. Check an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Mirabegron with Trimipramine?
MediHelp rates the interaction as moderate. Mirabegron and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is metabolised partly by CYP2D6, and mirabegron may raise its concentration. Higher levels can increase anticholinergic effects, sedation, orthostatic hypotension and cardiac conduction effects.
How serious is the interaction between Mirabegron and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider lowering the trimipramine dose. Check an ECG in patients with cardiac risk factors.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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