Drug interactions
Mirtazapine + Moxifloxacin
Severity: Moderate
Mirtazapine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been linked to QT prolongation, mainly at high doses or in overdose, and moxifloxacin adds to this effect. The combined arrhythmia risk is modest but relevant in patients with other risk factors.
What this interaction means in plain words
Mirtazapine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on ventricular repolarization.
What to do
Check the baseline QTc and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT, bradycardia or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Moxifloxacin?
MediHelp rates the interaction as moderate. Mirtazapine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has been linked to QT prolongation, mainly at high doses or in overdose, and moxifloxacin adds to this effect. The combined arrhythmia risk is modest but relevant in patients with other risk factors.
How serious is the interaction between Mirtazapine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT, bradycardia or other QT-prolonging drugs.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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