Drug interactions
Mirtazapine + Nabilone
Severity: Moderate
Mirtazapine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is strongly sedating through histamine blockade, and nabilone adds its own CNS depressant effects. The combination may cause excessive drowsiness, dizziness and impaired performance.
What this interaction means in plain words
Mirtazapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from cannabinoid agonism and antihistaminergic sedation.
What to do
Counsel on sedation and avoid driving until response is known; consider taking mirtazapine at bedtime. Reduce doses if daytime impairment persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Nabilone?
MediHelp rates the interaction as moderate. Mirtazapine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is strongly sedating through histamine blockade, and nabilone adds its own CNS depressant effects. The combination may cause excessive drowsiness, dizziness and impaired performance.
How serious is the interaction between Mirtazapine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving until response is known; consider taking mirtazapine at bedtime. Reduce doses if daytime impairment persists.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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