Drug interactions
Mirtazapine + Pentazocine
Severity: Moderate
Mirtazapine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is sedating and increases serotonergic and noradrenergic transmission, so with an opioid it can add to drowsiness and respiratory depression. Serotonin syndrome is possible but less likely with pentazocine than with strongly serotonergic opioids.
What this interaction means in plain words
Mirtazapine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mirtazapine belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from antihistaminic effects and opioid activity, with possible additive serotonergic effects.
What to do
Monitor for sedation and respiratory depression, and educate patients on features of serotonin syndrome. Lower doses if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Pentazocine?
MediHelp rates the interaction as moderate. Mirtazapine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is sedating and increases serotonergic and noradrenergic transmission, so with an opioid it can add to drowsiness and respiratory depression. Serotonin syndrome is possible but less likely with pentazocine than with strongly serotonergic opioids.
How serious is the interaction between Mirtazapine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and educate patients on features of serotonin syndrome. Lower doses if drowsiness is excessive.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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