Drug interactions
Mirtazapine + Tazemetostat
Severity: Minor
Mirtazapine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and is itself a CYP3A4 substrate, so it may modestly lower mirtazapine exposure. Mirtazapine is not a significant CYP3A4 inhibitor, so an effect on tazemetostat is unlikely.
What this interaction means in plain words
Mirtazapine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mirtazapine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tazemetostat increasing mirtazapine clearance.
What to do
Monitor antidepressant response and adjust the mirtazapine dose if effect diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Mirtazapine with Tazemetostat?
MediHelp rates the interaction as minor. Mirtazapine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and is itself a CYP3A4 substrate, so it may modestly lower mirtazapine exposure. Mirtazapine is not a significant CYP3A4 inhibitor, so an effect on tazemetostat is unlikely.
How serious is the interaction between Mirtazapine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and adjust the mirtazapine dose if effect diminishes.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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