Drug interactions
Mitomycin + Sotorasib
Severity: Minor
Mitomycin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-glycoprotein inducer that may lower exposure to P-gp substrates. The effect on mitomycin is theoretical and of uncertain clinical importance.
What this interaction means in plain words
Mitomycin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mitomycin belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Possible P-glycoprotein induction by sotorasib, potentially lowering mitomycin exposure.
What to do
No routine adjustment is needed; monitor for reduced mitomycin response if combined.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Mitomycin with Sotorasib?
MediHelp rates the interaction as minor. Mitomycin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a weak P-glycoprotein inducer that may lower exposure to P-gp substrates. The effect on mitomycin is theoretical and of uncertain clinical importance.
How serious is the interaction between Mitomycin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for reduced mitomycin response if combined.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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