Drug interactions
Mitomycin + Trastuzumab
Severity: Moderate
Mitomycin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin is a myelosuppressive cytotoxic agent, and trastuzumab given with myelosuppressive chemotherapy has been associated with higher rates of neutropenia and febrile neutropenia. This raises the risk of infection and may require treatment delays.
What this interaction means in plain words
Mitomycin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitomycin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity, with chemotherapy-induced bone marrow suppression being worsened by trastuzumab through a mechanism that is not fully defined.
What to do
Monitor complete blood counts regularly, particularly neutrophil counts, during combined therapy. Delay or reduce chemotherapy doses for significant neutropenia and treat fever promptly as febrile neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Mitomycin with Trastuzumab?
MediHelp rates the interaction as moderate. Mitomycin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin is a myelosuppressive cytotoxic agent, and trastuzumab given with myelosuppressive chemotherapy has been associated with higher rates of neutropenia and febrile neutropenia. This raises the risk of infection and may require treatment delays.
How serious is the interaction between Mitomycin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, particularly neutrophil counts, during combined therapy. Delay or reduce chemotherapy doses for significant neutropenia and treat fever promptly as febrile neutropenia.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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