Drug interactions
Mitomycin + Vincristine
Severity: Major
Mitomycin and Vincristine: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acute shortness of breath and severe bronchospasm have been reported when vinca alkaloids are given to patients who have received mitomycin, either before or at the same time. The reaction can be serious and may occur within minutes to hours of the vinca dose or later.
What this interaction means in plain words
Mitomycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitomycin belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
The mechanism is unknown, but additive or synergistic pulmonary toxicity is suspected.
What to do
Monitor respiratory status closely during and after treatment, and treat bronchospasm promptly with bronchodilators and corticosteroids. Stop therapy if serious pulmonary toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Vincristine?
MediHelp rates the interaction as major. Mitomycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acute shortness of breath and severe bronchospasm have been reported when vinca alkaloids are given to patients who have received mitomycin, either before or at the same time. The reaction can be serious and may occur within minutes to hours of the vinca dose or later.
How serious is the interaction between Mitomycin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status closely during and after treatment, and treat bronchospasm promptly with bronchodilators and corticosteroids. Stop therapy if serious pulmonary toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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