Drug interactions
Mitomycin + Vinorelbine
Severity: Major
Mitomycin and Vinorelbine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinca alkaloids given with or after mitomycin have been associated with acute dyspnea and severe bronchospasm. Pulmonary toxicity can be serious and may occur even after the mitomycin has been completed.
What this interaction means in plain words
Mitomycin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitomycin belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Probable additive or synergistic pulmonary toxicity; the exact mechanism is not established.
What to do
Monitor respiratory symptoms closely during and after treatment; stop therapy and give bronchodilators or corticosteroids if bronchospasm or interstitial changes develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vinorelbine
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Mitomycin with Vinorelbine?
MediHelp rates the interaction as major. Mitomycin and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vinca alkaloids given with or after mitomycin have been associated with acute dyspnea and severe bronchospasm. Pulmonary toxicity can be serious and may occur even after the mitomycin has been completed.
How serious is the interaction between Mitomycin and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms closely during and after treatment; stop therapy and give bronchodilators or corticosteroids if bronchospasm or interstitial changes develop.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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