Drug interactions
Mitotane + Vilazodone
Severity: Moderate
Mitotane and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer with a long duration of effect and can substantially lower vilazodone levels, risking loss of antidepressant efficacy.
What this interaction means in plain words
Mitotane and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Mitotane induction of CYP3A4 metabolism of vilazodone.
What to do
Monitor depressive symptoms and consider increasing the vilazodone dose within the labeled maximum. Induction persists for weeks after mitotane is stopped, so readjust the dose then.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Vilazodone?
MediHelp rates the interaction as moderate. Mitotane and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer with a long duration of effect and can substantially lower vilazodone levels, risking loss of antidepressant efficacy.
How serious is the interaction between Mitotane and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and consider increasing the vilazodone dose within the labeled maximum. Induction persists for weeks after mitotane is stopped, so readjust the dose then.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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