Drug interactions
Modafinil + Nabilone
Severity: Minor
Modafinil and Nabilone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness whereas nabilone is sedating, so each may partially blunt the other's effects. Nabilone can also cause tachycardia and mood disturbances that could be additive with the stimulating effects of modafinil.
What this interaction means in plain words
Modafinil and Nabilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Opposing pharmacodynamic effects on arousal; no well-established pharmacokinetic mechanism.
What to do
No routine adjustment is needed; monitor for anxiety, tachycardia or altered alertness. Do not assume modafinil makes it safe to drive after nabilone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabilone
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Nabilone?
MediHelp rates the interaction as minor. Modafinil and Nabilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness whereas nabilone is sedating, so each may partially blunt the other's effects. Nabilone can also cause tachycardia and mood disturbances that could be additive with the stimulating effects of modafinil.
How serious is the interaction between Modafinil and Nabilone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for anxiety, tachycardia or altered alertness. Do not assume modafinil makes it safe to drive after nabilone.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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